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Why did creatinine levels drop to 110 μmol/L after three years of peritoneal dialysis, and what should be done?

Nov 10, 2024 Source: Cainiu Health
Dr. Cao Zhiqiang
Introduction
Peritoneal dialysis usually refers to peritoneal dialysis. In general, a decrease in creatinine to 110 μmol/L after three years of peritoneal dialysis may be caused by factors such as reduced dietary intake, better kidney recovery, muscle atrophy, diabetic nephropathy, or leukemia. It is recommended that patients undergo general treatment, drug therapy, or chemotherapy under the guidance of a physician.

Peritoneal dialysis generally refers to peritoneal dialysis. Generally, a decrease in creatinine to 110 μmol/L after three years of peritoneal dialysis may be caused by reduced dietary intake, better kidney recovery, muscle atrophy, diabetic nephropathy, leukemia, and other reasons. It is recommended that patients undergo general treatment, drug therapy, and chemotherapy under a doctor's guidance. The specific analysis is as follows:

1. Reduced dietary intake: When patients undergo peritoneal dialysis, the drainage and discharge of dialysate may lead to a decrease in appetite, thereby reducing the intake of substances such as proteins and fats. Long-term reduced dietary intake, especially insufficient protein intake, can lead to decreased creatinine production, resulting in a creatinine level drop to 110 μmol/L after three years of peritoneal dialysis. Patients may experience discomfort such as abdominal pain and nausea. It is recommended to increase the intake of high-protein foods, such as eggs, milk, and lean meat, to improve malnutrition.

2. Better kidney recovery: Peritoneal dialysis can effectively remove waste and excess water from the body, thereby reducing the burden on the kidneys and promoting kidney function recovery. When kidney function recovers well, the ability to excrete creatinine also increases, leading to a decrease in creatinine to 110 μmol/L after three years of peritoneal dialysis. Patients whose kidney function has not fully recovered should continue peritoneal dialysis treatment to maintain internal stability.

3. Muscle atrophy: Long-term peritoneal dialysis may cause a reduction in patient activity, which can lead to muscle atrophy. Muscle atrophy reduces creatinine production from muscle metabolism, thus lowering blood creatinine levels. Patients may also experience fatigue. Patients should be encouraged to engage in appropriate physical exercise, such as walking and tai chi, to improve muscle condition.

4. Diabetic nephropathy: Diabetic nephropathy is one of the serious complications of diabetes and can lead to kidney function damage. Diabetic nephropathy patients may experience a decrease in creatinine to 110 μmol/L after three years of peritoneal dialysis, possibly due to increased creatinine excretion or abnormal muscle metabolism caused by kidney lesions. At this time, patients may experience edema. It is recommended to use hypoglycemic drugs as prescribed by a doctor, such as insulin glargine injection, insulin aspart injection, and insulin degludec injection, to control blood glucose levels and delay the progression of diabetic nephropathy.

5. Leukemia: Leukemia is a hematologic malignancy that can lead to abnormal bone marrow hematopoietic function. Leukemia patients may experience a decrease in creatinine to 110 μmol/L after three years of peritoneal dialysis, which may be due to renal dysfunction or abnormal muscle metabolism caused by leukemia cell infiltration. Chemotherapy is one of the main treatment methods for leukemia, killing leukemia cells through chemotherapy drugs to restore normal hematopoietic function of the bone marrow.

In daily life, patients should maintain a good mindset and positive lifestyle habits to promote physical recovery.

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