Can the "small three positives" truly become negative?
Dec 21, 2024
Source: Cainiu Health
Dr. Gao Jun
Introduction
"HBV small three positives" is a type of viral hepatitis B. Whether it can become negative mainly depends on the type of virus. Acute infections may become negative if treated promptly; some individuals may even clear the virus naturally. Patients with chronic infection usually have a long disease course and may not achieve seroclearance. They should seek timely medical treatment under a doctor's guidance to control disease progression and reduce liver damage.
Generally speaking, "small three positives" refers to the "hepatitis B small three positives" (HBsAg, HBeAg, and HBcAb positive). Whether the hepatitis B small three positives can become negative mainly depends on the type of hepatitis B virus. If it is an acute infection, there is a possibility of seroconversion to negative. However, if it is a chronic infection, seroconversion may not occur. If any discomfort arises, timely medical consultation is recommended. Detailed analysis is as follows:
If the patient has acute hepatitis B small three positives, timely treatment often offers the possibility of becoming HBsAg-negative. Additionally, teenagers and adults with strong immune systems may also experience spontaneous seroconversion, mainly through their own immune system clearing the virus. Patients are advised to relieve symptoms through appropriate increases in physical activity, balanced diet, and other lifestyle adjustments.
For patients with chronic hepatitis B small three positives, due to the longer disease course and possibly more pronounced symptoms, most patients require long-term or lifelong medication to control disease progression and reduce liver damage. These patients may not achieve seroconversion and should follow medical advice to promptly use medications such as adefovir dipivoxil tablets, lamivudine tablets, and entecavir tablets.
Regardless of the treatment method chosen, it should be conducted under the guidance of a physician to avoid self-medication. Additionally, regular follow-ups are recommended to monitor disease progression and adjust treatment plans accordingly.
