Is endometrial cancer associated with infertility?

Generally, endometrial cancer is associated with infertility to some extent. The detailed analysis is as follows:

Endometrial cancer is related to long-term estrogen stimulation, which may cause abnormal endometrial hyperplasia or even malignant transformation. This can interfere with normal menstrual cycles, ovulation, and endometrial preparation, thereby reducing fertility potential and increasing the risk of early miscarriage. In addition, pregnant women with endometrial cancer may encounter pregnancy complications such as preeclampsia, which are detrimental to maternal and fetal health. Moreover, treatments for endometrial cancer, including surgeries such as total hysterectomy combined with bilateral salpingo-oophorectomy, pelvic lymph node dissection, and chemotherapy, may directly affect the patient's fertility. Particularly, surgical treatment usually involves removal of the uterus and related adnexa, leading to loss of fertility.

For women planning pregnancy, paying attention to uterine health is very important. It is recommended to undergo regular gynecological examinations, especially for those with a family history or existing infertility issues, and to seek timely medical attention and actively pursue treatment under the guidance of professional doctors. At the same time, maintaining a balanced diet, engaging in moderate exercise, avoiding excessive obesity, and controlling blood pressure and blood glucose levels—thus maintaining a healthy lifestyle—can help reduce the risk of developing endometrial cancer.