How long do you have to take HIV post-exposure prophylaxis (PEP) medications?
Mar 03, 2025
Source: Cainiu Health
Dr. Bai Hongmei
Introduction
Post-exposure prophylaxis (PEP) for HIV typically needs to be taken continuously for 28 days to achieve diagnostic effectiveness. If the medication is taken for fewer than 28 days, the effectiveness of HIV prevention may be compromised, thereby increasing the risk of infection. Therefore, it is recommended to promptly use such medications under medical guidance. These medications primarily work by inhibiting the activity of viral protease to achieve the preventive effect.
Generally, HIV post-exposure prophylaxis (PEP) medications need to be taken continuously for 28 days. If there are any concerns, it is recommended to seek medical advice promptly. Detailed explanation is as follows:
HIV PEP is an emergency measure used to prevent HIV infection, and works by using a combination of antiviral medications. It is generally recommended to take the medication as soon as possible after a high-risk exposure. The usual course of treatment is 28 consecutive days to ensure effective prevention. If the duration is shorter than 28 days, the success rate of PEP may decrease, thereby increasing the risk of infection.
Commonly used HIV PEP medications include lamivudine and tenofovir disoproxil fumarate tablets, emtricitabine tablets, nevirapine capsules, etc. These drugs work by inhibiting the activity of HIV protease. However, during the course of treatment, medication should not be interrupted or the dosage reduced without medical advice. Additionally, further high-risk behaviors should be avoided during treatment to prevent compromising the effectiveness of PEP.
It should be noted that regardless of which PEP medication is chosen, it should be taken under the guidance of a physician to avoid self-medication. During the treatment period, regular monitoring is necessary. If symptoms such as nausea or vomiting occur, the medication should be discontinued promptly according to medical advice.
