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What are the side effects of aminophylline?

Mar 09, 2025 Source: Cainiu Health
Dr. Bai Hongmei
Introduction
Its side effects include gastrointestinal discomfort, central nervous system stimulation, polyuria, allergic reactions, and hematologic system impairment. When taking aminophylline, it is essential to strictly follow the doctor's instructions and prescription; do not adjust the dosage on your own. Additionally, if any of the aforementioned adverse symptoms occur during treatment, inform your doctor promptly so that the medication can be adjusted or appropriate measures taken.

Generally, aminophylline is available in various dosage forms such as tablets and injection solutions. Its side effects include gastrointestinal discomfort, central nervous system stimulation, polyuria, allergic reactions, and hematologic system damage, among others. Specifically:

1. Gastrointestinal Discomfort

Aminophylline can irritate the gastrointestinal mucosa. Common manifestations include nausea and vomiting, sometimes severe enough to expel gastric contents. Patients may also experience a burning sensation in the stomach accompanied by pain, and diarrhea may occur, leading to gastrointestinal dysfunction.

2. Central Nervous System Stimulation

Aminophylline can stimulate the central nervous system, causing symptoms such as headache and dizziness. Patients may feel heaviness and distension in the head, accompanied by vertigo. Insomnia may also occur, with the brain remaining in an excited state, making it difficult to fall asleep. Even when asleep, patients may experience vivid dreams and frequent awakenings, affecting sleep quality.

3. Polyuria

Aminophylline has a diuretic effect, increasing urinary output by the kidneys. Patients may experience frequent urination and increased urine volume, which can lead to loss of body fluids and electrolytes such as potassium and sodium, thereby affecting the body's internal environment stability.

4. Allergic Reactions

Some patients may develop allergic symptoms after using aminophylline, such as skin itching, which may lead to scratching and skin damage. Skin rashes may appear as red spots, patches, or papules on the skin, which may coalesce into larger areas in severe cases.

5. Hematologic System Damage

Aminophylline may inhibit bone marrow hematopoietic function, leading to decreased white blood cells and platelets, thus affecting the body's immune defense and coagulation functions. This can make patients more susceptible to infections and bleeding complications, increasing health risks.

When taking aminophylline, it is essential to strictly follow the doctor's instructions and prescriptions, and not to adjust the dosage on your own. Additionally, pay attention to your body's responses. If any of the above adverse symptoms occur during medication, promptly inform your doctor to adjust the treatment or take appropriate measures.

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