Can I undergo in vitro fertilization (IVF) during chemotherapy?

Mar 13, 2025 Source: Cainiu Health

Dr. Yang Ziqi

Introduction

In general, regardless of gender, it is not recommended to undergo in vitro fertilization (IVF) during chemotherapy. Chemotherapy drugs can have significant effects on the bodies of most patients undergoing treatment, particularly exerting direct negative impacts on the quality and quantity of eggs. Chemotherapy may lead to diminished ovarian function, poor follicular development, and other issues, thereby affecting the success rate of IVF.

Generally, under normal circumstances, both men and women are not advised to undergo in vitro fertilization (IVF) during chemotherapy. Detailed explanations are as follows:

Chemotherapy drugs may significantly affect the bodies of most patients undergoing treatment. For men, chemotherapy drugs may cause reduced sperm count, decreased sperm motility, increased sperm abnormalities, and even azoospermia (absence of sperm). Additionally, chemotherapy can impact the genetic material of sperm, potentially causing chromosomal abnormalities, and this effect may persist for a long time after chemotherapy ends.

For women, chemotherapy drugs may lead to diminished ovarian function, poor follicular development, and other issues, which can affect the success rate of IVF. Furthermore, chemotherapy might impact the health of the endometrium (uterine lining), causing it to become thinner or unsuitable for embryo implantation, thereby decreasing the likelihood of successful IVF and increasing the risk of early miscarriage.

At the same time, women undergoing chemotherapy are often in a physically weakened state and may be unable to tolerate the additional stress and risks associated with IVF. IVF procedures may involve injecting large amounts of hormonal medications and undergoing other treatments, which can place additional strain on the body.

Patients undergoing chemotherapy are advised to maintain a light diet, follow a regular sleep schedule, consume more nutrient-rich foods, and enhance their physical immunity.

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