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Can individuals with "small three positives" donate blood?

Jun 24, 2025 Source: Cainiu Health
Dr. Liu Feng
Introduction
Individuals with the 'minor three positives' (referring to specific hepatitis B serological markers) carry the hepatitis B virus in their bodies, and viral particles may exist in their blood. Transfusing blood containing the virus into a recipient can lead to hepatitis B transmission and increase the recipient's risk of infection. To ensure blood safety and prevent bloodborne disease transmission, blood donation standards explicitly state that individuals with the 'minor three positives' are not allowed to donate blood.

Generally, the term "small three positives" refers to the immunological markers of the hepatitis B virus in patients with chronic hepatitis B or hepatitis B virus carriers: specifically, the presence of hepatitis B surface antigen, hepatitis B e antibody, and hepatitis B core antibody. Individuals with these markers are generally not allowed to donate blood. Detailed explanation is as follows:

　　

Patients with "small three positives" carry the hepatitis B virus in their bodies, and viral particles may exist in their blood. If blood containing the virus is transfused into a recipient, it may transmit the hepatitis B virus and increase the recipient's risk of hepatitis B infection. To ensure blood safety and prevent transmission of diseases through blood, blood donation standards clearly state that individuals with "small three positives" are not allowed to donate blood.

Even if a patient with "small three positives" has normal liver function and low viral load, and appears to have a stable condition on the surface, the blood may still be infectious. Blood donation organizations, adhering to the principle of being responsible for recipients' health, do not allow anyone diagnosed with "small three positives" to donate blood regardless of the severity of their condition. This is a measure to control blood-borne disease transmission at the source.

Individuals with "small three positives" should undergo regular liver function and hepatitis B viral load tests, follow medical advice for proper disease management, and under no circumstances attempt to conceal their condition to donate blood, so as to avoid posing a risk to others' health.

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What are the benefits and risks of blood donation for women?
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Is blood donation beneficial for people with high blood pressure?
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How many milliliters is 400 cc of donated blood?
Donating 400 cc of blood is equivalent to donating 400 ml, as both units are exactly equal in volume. However, before donating blood, you should ensure adequate sleep and avoid donating on an empty stomach. Women should avoid donating blood three days before and after their menstrual period. If you have recently experienced symptoms such as cold, fever, or other discomfort, or if you suffer from infectious diseases, cardiovascular diseases, or other illnesses, you should not donate blood in order to ensure both the safety of blood donation and your own health.
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What is the maximum amount of blood one can donate?
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How many milliliters of blood does a normal person donate at one time?
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