What does it mean if transaminase levels are high during blood donation, and how can they be lowered?

Generally, elevated transaminase levels during blood donation may be caused by intense exercise, staying up late, viral hepatitis, fatty liver, cholecystitis, or other reasons. Depending on the specific situation, lifestyle adjustments or medical treatments can be adopted to improve the condition. A detailed analysis is as follows:

1. Intense Exercise

During exercise, muscle cells have active metabolism, and some damaged muscle cells release transaminases into the bloodstream, leading to elevated levels. Avoid high-intensity activities such as running or weightlifting recently; rest for 1–2 weeks before retesting. For daily exercise, prioritize gentle activities like walking or yoga.

2. Staying Up Late

Sleep deprivation affects liver metabolism and reduces the efficiency of liver cell repair, resulting in increased transaminase release into the blood. Ensure 7–8 hours of sleep each night, maintain a regular sleep schedule, avoid using electronic devices before bedtime, and open windows for ventilation upon waking.

3. Viral Hepatitis

Hepatitis B or C viruses invade liver cells, causing inflammation and necrosis, which leads to significant transaminase release. Under medical guidance, medications such as entecavir tablets, tenofovir alafenamide fumarate tablets, or lamivudine tablets may be prescribed. Liver function should be monitored regularly during treatment.

4. Fatty Liver

Excessive fat accumulation in liver cells impairs their normal function and causes transaminase leakage. Control dietary fat intake, and take silybin capsules, polyene phosphatidylcholine capsules, or diammonium glycyrrhizinate enteric-coated capsules as directed by a physician. Combine this with aerobic exercise three times per week.

5. Cholecystitis

Inflammation of the gallbladder spreads and stimulates the liver, affecting bile excretion and indirectly damaging liver cells. Under medical supervision, ursodeoxycholic acid capsules, anti-inflammatory and cholagogue tablets, or cefuroxime axetil tablets may be taken. Avoid fried and spicy foods in the diet. In severe cases, cholecystectomy may be required.

Maintain a regular routine and eat a light, balanced diet in daily life. Avoid excessive alcohol consumption and misuse of medications, and undergo regular liver function tests. If transaminase levels remain elevated, seek timely medical evaluation to identify the underlying cause. Do not self-medicate. Scientific lifestyle management supports long-term liver health.