What is the best medication for lowering uric acid?
Jul 10, 2025
Source: Cainiu Health
Dr. Yang Tiesheng
Introduction
Generally speaking, there is no single best medication for lowering uric acid. Commonly used medications for effectively reducing uric acid levels include febuxostat tablets, allopurinol tablets, benzbromarone tablets, probenecid tablets, and sodium bicarbonate tablets. Febuxostat tablets lower blood uric acid levels by inhibiting uric acid synthesis. They are suitable for long-term treatment of hyperuricemia in gout patients, take effect relatively quickly after administration, and have minimal impact on kidney function.
Generally speaking, there is no single best medication for lowering uric acid. Commonly used effective medications for reducing uric acid levels include febuxostat tablets, allopurinol tablets, benzbromarone tablets, probenecid tablets, and sodium bicarbonate tablets. Detailed explanations are as follows:
1. Febuxostat Tablets: Lower serum uric acid levels by inhibiting uric acid synthesis. They are suitable for long-term treatment of hyperuricemia in patients with gout. They act quickly after administration and have minimal impact on kidney function.
2. Allopurinol Tablets: Inhibit xanthine oxidase to reduce uric acid production. They are commonly used for primary and secondary hyperuricemia, especially hyperuricemia caused by excessive uric acid production.
3. Benzbromarone Tablets: Belong to the category of uricosuric agents that increase uric acid excretion and reduce serum uric acid concentration. They are suitable for patients with hyperuricemia who have normal or mildly impaired kidney function.
4. Probenecid Tablets: Promote uric acid excretion by inhibiting the reabsorption of uric acid in the renal tubules, thereby lowering serum uric acid levels. They are suitable for patients with hyperuricemia who are allergic or intolerant to allopurinol.
5. Sodium Bicarbonate Tablets: Alkalize urine, preventing uric acid from forming crystals in the urine and aiding its excretion. They are commonly used as an adjunctive treatment for patients with hyperuricemia or gout.
Selection of uric acid-lowering medications should be based on serum uric acid levels and overall health status. Regular monitoring of serum uric acid levels and liver and kidney function is necessary during treatment. Dosage adjustments must strictly follow medical advice, along with adherence to a low-purine diet and adequate water intake.
