Can erythema nodosum on the legs be cured?

Jul 11, 2025 Source: Cainiu Health
Dr. Liu Wenmin
Introduction
In most cases, erythema nodosum on the legs can be cured. If it is caused by an infection and there is no underlying disease, the condition can usually resolve with appropriate treatment. However, cases associated with severe underlying diseases or recurrent episodes may not be curable. When erythema nodosum is caused by a clear factor such as streptococcal infection and there are no other serious health problems, the nodules can gradually subside and the pain can be relieved with timely anti-inflammatory and anti-infective treatments.

Generally, erythema nodosum on the legs can be cured in most cases. If it is caused by infection and there is no underlying disease, it usually can be effectively treated. However, if accompanied by severe underlying conditions or recurrent episodes, complete resolution may not be possible. If any abnormalities occur, timely medical attention is recommended. Detailed explanation is as follows:

When erythema nodosum is caused by a clear factor, such as infection with streptococcus, and there are no other serious health conditions present, timely anti-inflammatory and anti-infective treatments can gradually resolve the nodules, relieve pain, and result in a good prognosis. In most cases, complete recovery is achievable.

If erythema nodosum occurs in association with autoimmune diseases such as Behçet's disease or sarcoidosis, or if it recurs frequently, the difficulty of treatment increases. The condition may become prolonged, with slow resolution of nodules and a tendency toward recurrence, making complete recovery less likely.

When erythema nodosum appears, it is important to identify the underlying cause as soon as possible and follow medical advice for standardized treatment. Self-medication or delaying treatment should be avoided. Additionally, adequate rest and minimizing irritation are important.

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