What is the reason for the interaction between cephalosporin drugs and durian?

Aug 07, 2025 Source: Cainiu Health

Dr. Yu Yongchao

Introduction

Durian contains a certain amount of sulfide compounds. These substances can inhibit the activity of a specific enzyme in the liver, through which cephalosporin antibiotics are metabolized. This metabolic process may be impeded, potentially leading to drug accumulation in the body. Cephalosporin metabolism primarily relies on the liver, and components in durian may affect normal liver function. Consuming durian simultaneously may increase the burden on the liver, which is detrimental to the body's normal drug metabolism.

There is an interaction between cephalosporin antibiotics and durian, which is generally related to the thiol compounds present in durian affecting drug metabolism, potentially increasing the burden on the liver, interfering with drug efficacy, increasing the risk of adverse reactions, and affecting the body's detoxification processes. Detailed analysis is as follows:

1. Thiols in durian affect drug metabolism: Durian contains certain thiol compounds that can inhibit the activity of an enzyme in the liver responsible for metabolizing cephalosporin antibiotics. This interference may lead to drug accumulation in the body.

2. Potential increase in liver burden: The metabolism of cephalosporin antibiotics mainly relies on the liver, and components in durian may affect normal liver function. Consuming both together increases the liver's workload, impairing normal drug metabolism.

3. Interference with drug efficacy: Certain components in durian may chemically react with cephalosporin antibiotics, altering their original chemical structure, thereby interfering with their antibacterial activity and reducing therapeutic effectiveness.

4. Increased risk of adverse reactions: When consumed together, they may irritate the gastrointestinal tract, causing symptoms such as nausea, vomiting, and may also affect the nervous system, increasing the likelihood of adverse effects such as dizziness and headaches.

5. Impact on the body's detoxification processes: Specific mechanisms are required for the body to detoxify cephalosporin antibiotics. Components in durian may disrupt these mechanisms, preventing timely elimination of drug toxicity and potentially causing harm to the body.

During treatment with cephalosporin antibiotics, durian should be avoided, and the interval between consumption should be at least one week. If both are inadvertently ingested together, close attention should be paid to physical condition, and medical attention should be sought promptly if any discomfort occurs, with full disclosure to the doctor for appropriate management.

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Can durian be eaten?

Under normal circumstances, durian can be consumed, but it is important to eat it in moderation. When eating durian, choose ripe fruits, as unripe durians have poor taste and may be difficult to digest. Do not consume excessive amounts at one time to avoid discomfort caused by high sugar and calorie intake. Individuals with underlying medical conditions such as diabetes or kidney disease should consult their doctor before consumption.

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Can sunflower, cucumber, durian, and luffa be eaten together?

Under normal circumstances, sunflower seeds, cucumbers, durian, and luffa can be consumed together, with attention to moderate portions. When consuming these foods: 1. Durian has a relatively high sugar content; excessive intake at one time is not recommended, especially for individuals with elevated blood sugar levels, who should control their intake. 2. Sunflower seeds are rich in oils and may increase digestive burden if consumed in excess. 3. When combining all four foods, the total quantity should be adjusted according to individual digestive capacity.

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Besides eating durian, what else can I eat for dizziness?

Under normal circumstances, in addition to eating durian, dizziness can also be alleviated by consuming foods such as red dates, bananas, spinach, walnuts, and yam. Moreover, during episodes of dizziness, one may appropriately consume foods like millet and longan. It is important to maintain regular eating habits in daily life, avoid excessive fatigue, and if dizziness occurs frequently or symptoms persist, seek timely medical attention to identify the underlying cause.