How many doses of the quadrivalent HPV vaccine are required?

Nov 06, 2025 Source: Cainiu Health

Dr. Zhang Lu

Introduction

For individuals aged 9–14 years receiving the quadrivalent HPV vaccine for the first time and who have no contraindications to vaccination, a 2-dose schedule at 0 and 6–12 months is recommended. This age group typically exhibits a strong immune response, and two doses are sufficient to achieve optimal protective efficacy. This approach not only reduces the number of injections but also minimizes inconvenience associated with multiple visits, aligning with vaccination guidelines in most countries and regions.

Generally, the number of doses for quadrivalent HPV vaccine depends on the recipient's age and immunization history. Individuals aged 9–14 may receive two doses, while those aged 15 and above require three doses. Special cases should follow medical advice for adjustments. If in doubt, it is recommended to consult a healthcare provider in advance. Detailed information is as follows:

For individuals aged 9–14 receiving the quadrivalent HPV vaccine for the first time and who have no contraindications to vaccination, a two-dose schedule at 0 and 6–12 months is recommended. This age group typically exhibits a strong immune response, and two doses are sufficient to achieve optimal protection. This approach reduces the number of injections and minimizes inconvenience associated with multiple visits, aligning with vaccination guidelines in most countries and regions.

Individuals aged 15 and above (including adult females and males) receiving the quadrivalent HPV vaccine for the first time should complete a three-dose series according to a 0-, 2-, 6-month schedule. The immune response to the vaccine in this age group differs from that in adolescents, and three doses are necessary to ensure adequate and long-lasting antibody production for effective protection. If an individual has previously received another type of HPV vaccine, a healthcare provider should assess the need for additional doses of the quadrivalent vaccine to avoid unnecessary or inappropriate dosing.

Prior to vaccination, individuals should inform their doctor about their health status and any history of allergies to identify potential contraindications. After vaccination, monitor for local reactions at the injection site. Seek prompt medical attention if severe redness, swelling, pain, or fever occurs.

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What types of HPV infection can the HPV vaccine prevent?

Under normal circumstances, HPV refers to human papillomavirus. The human papillomavirus vaccine can prevent infections caused by various types of human papillomavirus, including human papillomavirus type 16 infection, human papillomavirus type 18 infection, human papillomavirus type 6 infection, human papillomavirus type 11 infection, human papillomavirus type 31 infection, and others.

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What are the most serious side effects of the 9-valent vaccine?

Under normal circumstances, the 9-valent recombinant human papillomavirus (HPV) vaccine may cause side effects such as severe allergic reactions, fainting, joint pain and swelling, thrombocytopenic purpura, and menstrual disorders. Receiving the 9-valent recombinant HPV vaccine and maintaining healthy lifestyle habits can effectively reduce the risk of HPV infection and protect one's health.

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Is the HPV vaccine effective for individuals who are already infected?

The human papillomavirus (HPV) vaccine is effective against HPV types to which an individual has not yet been exposed, but it is not effective against HPV types that an individual has already contracted. If a person is already infected with HPV type 58, the vaccine will not prevent infection from this type; however, it can still prevent infection from other types not yet encountered, such as HPV types 1, 2, 3, 4, and so on. It is important to understand one's infection status before vaccination and to comprehensively assess the necessity of vaccination.

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Can I get a nucleic acid test after receiving the HPV vaccine?

In general, whether nucleic acid testing can be performed after receiving the HPV vaccine depends on the purpose of the test. After getting the HPV vaccine, if nucleic acid testing is needed, you should inform healthcare providers about the type and timing of the vaccine received. For COVID-19 nucleic acid testing, there is no need to adjust the testing schedule due to HPV vaccination. However, for HPV virus testing, it is essential to consult a doctor to determine the appropriate timing for testing.