Is agomelatine tablet effective for mild depression?

Agomelatine tablets are an antidepressant primarily used to treat major depressive disorder in adults. For patients with mild depression, the suitability of this medication should be determined based on individual circumstances. If depressive symptoms are present, it is recommended to seek timely medical evaluation. Details are as follows:

For patients with mild depression who experience significant anxiety and insomnia, and whose symptoms—after medical evaluation—seriously affect daily functioning, short-term use of this medication under physician guidance may be considered, provided contraindications such as a history of substance abuse or severe liver/kidney dysfunction are ruled out. The drug can rapidly alleviate anxiety and improve sleep quality, thereby creating favorable conditions for psychotherapy and self-regulation.

For patients with mild depression who do not have prominent anxiety or insomnia, or who have a history of substance dependence or respiratory disorders, this medication is not recommended. It is not the first-line treatment for core depressive symptoms, and prolonged use may lead to dependence. Withdrawal symptoms may occur upon discontinuation, which could hinder recovery. In such cases, psychotherapy or other more appropriate treatment approaches should be prioritized.

Daily care should encourage regular sleep patterns and a light, balanced diet. Patients should be accompanied and encouraged to participate in relaxing activities such as walking and meditation to help manage negative emotions. A supportive and inclusive family environment should be fostered, avoiding verbal provocations. Ensure that patients adhere to prescribed treatments, attend regular follow-up appointments, and promptly communicate with their doctor if mood fluctuations or adverse drug reactions occur, so that treatment plans can be adjusted accordingly.