Can I take dydrogesterone tablets if I have uterine fibroids?

Generally, if a patient has uterine fibroids but there is no significant risk of fibroid growth and treatment is medically necessary, duphaston (dydrogesterone) tablets may be taken under a doctor's guidance. However, if the fibroids are large, growing rapidly, or accompanied by hormone-sensitive symptoms, self-administration is not recommended. In case of uncertainty, it is advisable to consult a healthcare provider in advance. Detailed analysis is as follows:

If the uterine fibroid is smaller than 5 cm in diameter, grows slowly, and causes no obvious symptoms such as heavy menstrual bleeding or abdominal pain, and if the patient experiences menstrual irregularities or low progesterone levels in early pregnancy requiring fetal support, short-term use of dydrogesterone may be considered after medical evaluation. In such cases, the medication primarily serves to regulate hormones and maintain pregnancy, with minimal impact on the fibroid.

If the fibroid is larger than 5 cm in diameter, shows rapid growth, or is associated with明显 symptoms such as increased menstrual flow or anemia, dydrogesterone—being a progestin—may stimulate fibroid growth and worsen symptoms. Moreover, in patients with progesterone-dependent fibroids, taking the drug could lead to an increase in fibroid size. In these cases, the medication should be avoided, and management of the fibroid should take priority.

Patients with uterine fibroids must undergo a comprehensive evaluation by a physician to assess both fibroid status and the necessity of medication before using dydrogesterone. Regular ultrasound follow-ups during treatment are essential to monitor any changes in fibroid size.