What is the relationship between luteinizing hormone and progesterone?

Under normal circumstances, luteinizing hormone (LH) promotes the formation and maturation of the corpus luteum in the ovary. The corpus luteum is the primary tissue responsible for progesterone secretion, and these two hormones share a regulatory and interdependent relationship during the female reproductive cycle. If there are any concerns, it is recommended to seek medical consultation early. Detailed analysis is as follows:

In a normal menstrual cycle, luteinizing hormone peaks before ovulation, triggering follicular rupture and ovum release. Subsequently, the ruptured follicle develops into the corpus luteum. Under the continuous influence of LH, the corpus luteum gradually matures and begins to secrete large amounts of progesterone. Progesterone helps maintain endometrial stability, preparing the uterus for possible implantation. At this stage, the coordinated actions of LH and progesterone ensure the normal progression of the reproductive cycle.

If LH secretion is abnormal—for example, if the peak level is insufficient or its duration too short—it may lead to inadequate corpus luteum development or premature degeneration, resulting in reduced progesterone production. In such cases, the endometrium cannot be maintained in an optimal state, potentially causing menstrual cycle irregularities, infertility, or early miscarriage. This demonstrates the interdependent impact between LH and progesterone when either is dysregulated.

Monitoring LH and progesterone levels should take into account the phase of the menstrual cycle. Any abnormal values should prompt timely medical evaluation to identify underlying causes. Self-diagnosis should be avoided to prevent delays in appropriate management or treatment, thereby safeguarding reproductive health.