Is it sufficient to take only one medication for treating depression?

Nov 20, 2025 Source: Cainiu Health

Dr. Zhang Baohua

Introduction

If depression is moderate or more severe, or if symptoms show no significant improvement—or even worsen—after taking one antidepressant for a period of time, or if intolerable side effects occur, monotherapy with a single medication is not recommended. Physicians typically consider switching to a different class of antidepressant or adding another type of medication to the existing regimen to enhance treatment efficacy and better control the condition.

Generally, antidepressant medication may be used as monotherapy in certain cases, which is acceptable for mild depression when a single drug proves effective. However, it is not recommended for severe depression or when a single medication fails to provide sufficient relief. If there are any concerns, it is advisable to consult a healthcare professional early. Detailed explanations are as follows:

If depression is in the mild stage and symptoms have minimal impact on daily life, using a single antidepressant with adequate dosage and sufficient treatment duration may lead to significant symptom improvement. In cases where no serious side effects occur and the patient tolerates the medication well, continued monotherapy may be appropriate without the need for additional medications.

However, if depression is moderate to severe, or if symptoms show no clear improvement—or even worsen—after a period of taking a single antidepressant, or if intolerable side effects develop, monotherapy is generally not recommended. Physicians typically consider switching to a different medication or combining additional types of drugs with the current one to enhance treatment efficacy and achieve better symptom control.

The selection of type and number of medications for treating depression should be determined by a psychiatrist based on a comprehensive assessment of the individual's condition. Patients should never adjust their medication dosage or regimen independently. Regular follow-up visits are essential during treatment to monitor therapeutic response and physical side effects, ensuring both safety and effectiveness of therapy.

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