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What are the side effects of sertraline hydrochloride tablets?

Nov 21, 2025 Source: Cainiu Health
Dr. Zhang Baohua
Introduction
In general, the possible side effects of sertraline hydrochloride tablets mainly include gastrointestinal reactions, neurological symptoms, sexual dysfunction, changes in mood and sleep, metabolic and skin reactions. Most side effects occur during the initial phase of treatment and tend to diminish as the body adjusts. There is significant individual variation in side effects. Patients should follow their doctor's instructions for regular dosing and must not adjust the dosage on their own.

Generally, the potential side effects of sertraline hydrochloride tablets mainly include gastrointestinal reactions, neurological symptoms, sexual function disturbances, emotional and sleep changes, metabolic issues, and skin reactions. Most side effects occur during the initial phase of treatment and gradually diminish as the body adapts. A detailed analysis is as follows:

1. Gastrointestinal reactions: These are the most common side effects in the early stages of treatment, including nausea, dry mouth, diarrhea, or constipation, with some individuals experiencing mild abdominal pain. These symptoms typically appear within 1–2 weeks after starting the medication, are usually mild in severity, and gradually improve as the body adjusts.

2. Neurological symptoms: Common symptoms include dizziness, headache, and drowsiness; a few individuals may experience tremors or difficulty concentrating. These are often related to the drug’s modulation of neurotransmitters and are most noticeable at the beginning of treatment. Most people develop tolerance over time with continued use.

3. Sexual function impact: Some patients may experience reduced libido, delayed ejaculation, or decreased sexual pleasure. This side effect is often overlooked but can affect quality of life.

4. Emotional and sleep changes: A minority of patients may experience temporary worsening of anxiety, irritability, insomnia, or disrupted sleep such as vivid dreams during the initial treatment phase. These are part of the body's adaptation process and are typically short-lived.

5. Metabolic and skin reactions: Long-term use may lead to minor weight changes, while a small number of individuals may develop rashes or increased sweating. Weight fluctuations can be managed through diet and exercise, and rashes are generally benign.

Side effects vary significantly among individuals. It is essential to take the medication as prescribed by a physician and avoid adjusting the dosage independently. Maintaining a light diet and regular lifestyle is recommended. If side effects persist or worsen, consult your doctor promptly to adjust the treatment plan, ensuring optimal efficacy while minimizing discomfort.

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