Can oral medication be taken at the same time as receiving long-acting paliperidone injections?

When receiving long-acting paliperidone injections, specific medications may be taken concurrently under a doctor's guidance. Long-acting paliperidone is used to treat conditions such as schizophrenia. Combination therapy should be based on clinical needs, avoiding contraindicated drugs, and strictly following medical instructions to adjust the treatment plan. If excessive drowsiness, dizziness, or significant mood fluctuations occur after combining medications, prompt medical consultation is recommended.

Long-acting paliperidone injections provide stable control of psychiatric symptoms through sustained release of the active ingredient, acting on the central nervous system. In clinical practice, additional symptomatic medications are often prescribed according to patients' comorbidities, such as anxiety or insomnia, and it generally has no absolute contraindications with most commonly used drugs.

However, self-administered combination with central nervous system depressants or other antipsychotics should be avoided to prevent worsening side effects such as sedation or extrapyramidal symptoms. Before combining any medication, all current medications must be disclosed to the doctor, who will assess potential drug interactions.

During treatment, injections should be administered regularly, and any concomitant medications should be taken on schedule—avoid missing doses or stopping medications without medical advice. Maintain a light diet, avoid alcohol and stimulant foods, and keep a consistent daily routine to support optimal medication effectiveness.