What should be considered when using tretinoin cream?
Nov 29, 2025
Source: Cainiu Health
Dr. Liu Wenmin
Introduction
When using tretinoin cream, it is important to establish skin tolerance, strictly adhere to sun protection, control the duration of use, avoid contact with sensitive areas, and monitor skin reactions. For initial use, start with a low frequency—such as every other day or every two days—applying a small amount thinly. Only after the skin has adapted should the frequency and dosage be gradually increased, avoiding direct or excessive application that may cause severe irritation.
Generally, when using tretinoin cream, it is important to establish skin tolerance, strictly perform sun protection, control application time, avoid contact with sensitive areas, and monitor skin reactions. Specific details are as follows:
1. Establish skin tolerance: For initial use, start with a low frequency—such as every other day or every two days—and apply a small amount thinly. Gradually increase the frequency and dosage only after the skin has adapted, to avoid severe irritation from immediate, extensive application.
2. Strict sun protection: During use, the skin becomes more sensitive to ultraviolet (UV) rays. Without proper sun protection, the skin may become darkened, red, painful, or even develop sunspots. Apply sufficient sunscreen daily, and combine with physical protection such as hats and umbrellas when outdoors.
3. Control application time: It is recommended to apply the cream at night before bedtime, as tretinoin degrades easily when exposed to light. Nighttime application ensures optimal efficacy and reduces additional daytime UV-induced skin irritation, helping maintain drug effectiveness and minimize discomfort.
4. Avoid contact with sensitive areas: Keep the cream away from delicate and sensitive areas such as around the eyes, corners of the mouth, and sides of the nose. These regions have thinner skin barriers and are prone to redness and stinging from irritation. If accidental contact occurs, rinse thoroughly with water immediately.
5. Monitor skin reactions: Mild dryness, flaking, and redness may occur during treatment and are typically normal initial responses that can be alleviated with enhanced moisturization. However, if severe stinging, swelling, or peeling develops, discontinue use immediately and consult a healthcare professional.
Before applying tretinoin cream, cleanse the skin and allow it to dry completely. Avoid combining it with other irritating skincare products. Pregnant women, those planning pregnancy, and breastfeeding individuals should not use this product unless directed by a physician. For long-term use, regular follow-up visits are recommended so that professionals can assess skin condition and adjust the treatment plan accordingly.
