Does the drug vardenafil affect male sperm?

Dec 08, 2025 Source: Cainiu Health

Dr. Cao Zhiqiang

Introduction

Long-term overdose or擅自 adjusting dosage may lead to systemic metabolic imbalance, indirectly affecting the stability of the internal environment in the reproductive system. In a few individuals with underlying reproductive system diseases or special constitutions, changes in sperm parameters may occur; however, such cases are not directly caused by the drug and are mostly related to individual conditions.

Under normal circumstances, when taken as prescribed, vardenafil does not affect male sperm, and there is no clear evidence indicating that it damages sperm quality; however, extreme or improper use should be monitored. If concerned, individuals are advised to consult a healthcare provider in advance. Detailed analysis is as follows:

Vardenafil primarily works by enhancing vasodilation in the penile blood vessels to alleviate erectile dysfunction, and it does not directly act on the testicular spermatogenic tissue or sperm themselves. In clinical practice, men who use the medication properly typically maintain normal levels of key sperm parameters such as count and motility, without significant abnormal fluctuations.

However, long-term excessive use or unauthorized dosage adjustments may lead to systemic metabolic imbalances, indirectly affecting the stability of the reproductive system's internal environment. In rare cases, individuals with pre-existing reproductive conditions or unique physical constitutions may experience changes in sperm parameters, but these are generally not caused directly by the drug and are more likely related to individual health status.

The medication must be used strictly according to medical guidance, avoiding self-medication or prolonged misuse. Men planning for fatherhood should inform their doctor before starting the drug and, if necessary, undergo sperm quality testing. If any discomfort in the reproductive system occurs during treatment, prompt medical evaluation is recommended. Additionally, maintaining healthy lifestyle habits and a balanced diet is essential for preserving reproductive function.

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What are the causes of male infertility?

Male infertility may be caused by unhealthy lifestyle habits, excessive mental stress, varicocele, prostatitis, oligoasthenospermia, and other factors. It can be improved through lifestyle adjustments, emotional regulation, and medical treatments. If pregnancy is not achieved after one year of trying, timely medical evaluation is necessary. Long-term sleep deprivation, smoking, excessive alcohol consumption, and prolonged sitting can impair reproductive system function and lead to decreased sperm quality.

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Who is Jin Suo Gu Jing Wan suitable for?

Jinsuo Gujing Pill, a commonly used Chinese patent medicine belonging to the category of astringents, is primarily suitable for men with kidney deficiency and instability, individuals with soreness and weakness in the lower back and knees, those suffering from insomnia and excessive dreams, fatigue and lack of energy, as well as those experiencing frequent episodes of nocturnal emission or spermatorrhea. It is especially appropriate for men whose seminal fluid leakage results from kidney deficiency, typically manifesting as nocturnal emissions or involuntary ejaculation, symptoms which often worsen after physical exertion or emotional fluctuations.