Can myelofibrosis be cured?

In general, myelofibrosis currently cannot be completely cured. However, various treatment methods can help control the disease, alleviate symptoms, and improve quality of life. The detailed analysis is as follows:

The pathogenesis of myelofibrosis is closely related to abnormal clonal proliferation of hematopoietic stem cells. The disease progressively destroys the normal hematopoietic microenvironment of the bone marrow, promoting excessive proliferation of fibrous tissue that replaces normal hematopoietic tissue. This pathological change involves complex cellular-level abnormalities and progresses over time. Current medical treatments are unable to fully reverse the structural damage to the bone marrow or correct the abnormal cell clones; therefore, a complete cure is not yet possible. Treatment primarily focuses on alleviating hematopoietic failure and managing complications.

Daily care should emphasize creating a comfortable and clean recuperative environment for patients, ensuring adequate rest and avoiding excessive fatigue. Diet should be nutritious and easy to digest, with increased intake of protein- and vitamin-rich foods, along with sufficient hydration. Patients' physical conditions should be closely monitored, and medical attention should be sought promptly if symptoms such as worsening fatigue, bleeding, or fever occur. In addition, maintaining open communication with the patient to reduce psychological stress and support a positive mindset can enhance cooperation with the treatment process.