Is IgA nephropathy an autoimmune disease?

IgA nephropathy is generally considered an autoimmune disease. It is the most common type of primary glomerular disease and falls under the category of immune-mediated kidney disorders. The condition is typically diagnosed through a kidney biopsy, which reveals deposits of immunoglobulin A (IgA) — either predominantly or exclusively — within the glomeruli, the filtering structures of the kidney. These IgA deposits lead to clinical manifestations such as hematuria and proteinuria in affected patients.