Is an aspartate aminotransferase (AST) level over 100 a serious condition?
Disease description:
I had a liver check-up this week, and they told me my aspartate aminotransferase (AST) level is over 100. I'm really curious—how serious is an AST level above 100?
Doctor's answer (1)
Dr. Gao Jun
The normal reference range for aspartate aminotransferase (AST) is typically 0–40 U/L. Levels exceeding this range may indicate abnormal liver function or damage to related tissues. When AST levels rise to over 100 U/L, they are above the normal range; however, the clinical significance of this elevation depends on the individual patient's specific circumstances.
Mild elevations may result from physiological factors such as alcohol consumption, intense physical exercise, or inadequate rest. In such cases, the increase is generally not serious and may return to normal after lifestyle adjustments. However, if elevated AST is accompanied by other abnormal liver function indicators—such as increased bilirubin—or if there are underlying pathological conditions like viral hepatitis or cirrhosis—it may suggest more significant liver damage.
Furthermore, AST is also present in tissues such as cardiac muscle and skeletal muscle. Elevated AST levels may therefore also indicate injury to these tissues. Persistent elevation of AST warrants timely medical evaluation.
