Is it normal for the testicles to be different sizes?

Is it normal for the testicles to be different in size? The answer depends on the degree of difference and whether there are associated functional abnormalities. In healthy males, it is common for the two testicles to differ slightly in size, although this difference is usually not significant. If the size discrepancy is minor and testicular function is normal, the condition is generally considered normal and no cause for concern. However, if there is a substantial difference in testicle volume or if functional problems arise—such as reduced semen volume or sexual dysfunction—this may indicate an underlying abnormality. In such cases, it is important to seek medical evaluation promptly to rule out potential conditions such as orchitis, epididymitis, testicular cysts, or testicular tumors.