What is the main cause of early shock in hemorrhagic fever with renal syndrome?

Hemorrhagic fever with renal syndrome (HFRS) early shock is primarily caused by Hantavirus infection, which leads to severe damage of small blood vessels throughout the body, resulting in a significant increase in vascular wall permeability. This pathological change causes a large amount of plasma from the blood to leak out of the vessels, leading to a sharp decrease in intravascular blood flow and a subsequent marked drop in blood pressure. This cascade of events ultimately triggers the onset of shock. HFRS is a severe, life-threatening zoonotic infectious disease with high mortality. Early recognition and active treatment are crucial for improving patient prognosis. During treatment, it is necessary to rapidly replenish blood volume, correct acidosis, and closely monitor vital signs such as renal function to effectively control disease progression.