Is methimazole harmful to liver and kidney function?

Methimazole (commonly referring to thiamazole) indeed has certain potential adverse effects on liver and kidney function. 1. Renal side effects: Thiamazole may cause kidney function impairment, including drug-induced nephropathy. By inhibiting thyroid hormone synthesis, it enhances the diuretic effect, leading to water and electrolyte imbalance and indirectly increasing the burden on the kidneys. In severe cases, it may induce or exacerbate renal failure. 2. Hepatic side effects: Thiamazole may cause abnormal liver function, resulting in elevated transaminase and bilirubin levels. This is because thiamazole can cause liver inflammation and necrosis, leading to liver cell damage. Patients may experience gastrointestinal symptoms such as nausea, vomiting, and loss of appetite. Long-term liver dysfunction may also lead to cirrhosis. During the use of thiamazole, regular monitoring of liver and kidney function is necessary to promptly detect and manage any potential issues.