Complications of Ichthyosis

The complications of ichthyosis mainly include: 1. Ichthyosis-spastic diplegia-mental retardation syndrome: This is a rare syndrome composed of congenital ichthyosis, spastic limb paralysis, and mental retardation, which significantly impacts the patient's ability to perform activities of daily living. 2. Ichthyosis-midget-mental retardation syndrome: This syndrome involves ichthyosiform erythroderma, dwarfism, mental retardation, and spastic paralysis. Patients often exhibit short stature, intellectual disability, and motor impairments of the limbs. 3. Mental retardation-epilepsy-ichthyosis syndrome: This condition manifests in infancy, primarily presenting as a triad of mild ichthyosiform erythroderma, mental retardation, and epilepsy. Some patients may also have symptoms such as underdeveloped genitalia. 4. Ichthyosis-hepatosplenomegaly-ataxia syndrome: Patients may experience hepatosplenomegaly, ataxia, and dysarthria, causing damage to the nervous system and internal organs. 5. Ichthyosis-multiple neuritis-ataxia syndrome: This is a rare autosomal recessive disorder mainly characterized by neurological involvement, such as ataxia, muscle weakness, and diminished or absent deep reflexes. 6. Other complications: Such as trichorrhexis-mental retardation-ichthyosis syndrome, which presents with brittle hair caused by hair shaft abnormalities and mental retardation; and ichthyosis-pili torti-hereditary allergy syndrome, which involves pili torti (twisted hair) and hereditary allergic diathesis.