How can ichthyosis be prevented from being inherited?

Jul 16, 2024 Source: Cainiu Health
Disease description:

My husband has had ichthyosis for many years. We are now planning to have a child and would like to consult on how to prevent ichthyosis from being inherited.

Doctor's answer (1)
Dr. Wang Xiaoyan
To prevent the heredity of ichthyosis, the following measures can be taken: 1. Avoid consanguineous marriage: Marrying within close relatives significantly increases the probability of genetic mutations, thereby increasing the risk of inheriting ichthyosis. Therefore, marriages between close relatives should be avoided. 2. Undertake premarital counseling and genetic testing: Before marriage, both partners can undergo genetic counseling and testing to determine whether they carry genes associated with ichthyosis. This helps assess the hereditary risk and make more informed decisions regarding childbearing. 3. Choose a partner without ichthyosis: If one partner has ichthyosis, it is advisable to choose a partner who does not have the condition to reduce the risk of the offspring inheriting the disease. 4. Consider assisted reproductive technologies: For couples who are already carriers of the ichthyosis gene, assisted reproductive technologies such as preimplantation genetic testing (third-generation IVF technology) can be considered. This involves selecting healthy embryos for transfer, thereby reducing the risk of the disease in offspring.