Causes of Elevated Alanine Aminotransferase (ALT)
Disease description:
Recently, I went to the hospital for a liver function test, and the results showed that my alanine aminotransferase (ALT) level is elevated. May I ask what might be the cause of this?
Doctor's answer (1)
Dr. Yang Ziqi
Elevated alanine aminotransferase (ALT) levels can be caused by various factors, typically closely related to liver function impairment. The main causes include:
1. Viral hepatitis: Infections such as hepatitis A, B, C, D, and E are among the most common causes.
2. Alcoholic liver disease: Long-term heavy alcohol consumption can lead to alcoholic fatty liver, alcoholic hepatitis, and alcoholic cirrhosis, all of which can cause elevated ALT levels.
3. Drug or toxin-induced injury: Certain medications (e.g., acetaminophen, anti-tuberculosis drugs) and chemicals (e.g., carbon tetrachloride) can cause liver cell damage, resulting in increased ALT levels.
4. Biliary tract diseases: Conditions such as cholelithiasis (gallstones) and cholangitis (bile duct inflammation) can indirectly affect liver function due to biliary obstruction or inflammation, leading to elevated ALT levels.
5. Non-pathological factors: Vigorous exercise, staying up late, excessive fatigue, pregnancy, and similar conditions may also cause transient elevations in ALT levels.
6. Other causes: Infections (e.g., cytomegalovirus, Epstein-Barr virus), tumors, and liver trauma can also contribute to elevated ALT levels.
If you have concerns, it is recommended to seek medical advice promptly.
