Can taking traditional Chinese medicine cause elevated transaminase levels?

Mar 24, 2025 Source: Cainiu Health
Disease description:

I am a 42-year-old male. Recently, I have been taking traditional Chinese medicine (TCM) to improve my health. However, I heard that TCM may affect the liver. I am very concerned—can taking TCM cause elevated transaminase levels?

Doctor's answer (1)
Dr. Zhang Xiuhong

Consumption of traditional Chinese medicine (TCM) may cause elevated transaminase levels, although not all TCMs lead to this condition. Certain TCM ingredients may impose a metabolic burden on the liver, especially when used long-term or in excessive amounts, including some herbs with known hepatotoxicity such as Polygonum multiflorum (He Shou Wu) and Tripterygium wilfordii (Lei Gong Teng). Additionally, individual differences can affect the liver's tolerance to medications, and some people may be more prone to liver function abnormalities due to constitutional factors. When TCM prescriptions are properly formulated, administered at appropriate dosages, and used under medical supervision, they generally do not cause significant liver damage.

To ensure safe medication use, it is recommended to regularly monitor liver function indicators, especially during long-term TCM treatment. If transaminase levels are found to be significantly elevated, prompt consultation with a physician is advised to adjust the medication regimen or discontinue suspected drugs. It is important to obtain TCM prescriptions from legitimate healthcare institutions and avoid self-medicating with herbs or supplements of unknown origin. Additionally, maintaining a healthy lifestyle by avoiding alcohol consumption and high-fat diets can help reduce the burden on the liver. By employing scientific medication practices and undergoing regular check-ups, the risk of drug-induced liver injury can be effectively minimized.