Can vinegar and cephalosporin be taken together?

Mar 31, 2025 Source: Cainiu Health
Disease description:

I've had a toothache for several days and went to buy cephalosporin to take, then I wanted to drink vinegar along with it. Can vinegar be taken together with cephalosporin?

Doctor's answer (1)
Dr. Yang Ziqi

Cephalosporin antibiotics are a class of broad-spectrum antimicrobial agents widely used in the treatment of various infections. Vinegar, as a common condiment, primarily consists of acetic acid. There is no interaction or adverse reaction between vinegar and cephalosporins; therefore, vinegar and cephalosporins can be consumed together.

However, vinegar may affect the pH level in the stomach, and the absorption of certain cephalosporin drugs can be influenced by gastric acid. Although this effect is generally minimal, it may be a concern for specific individuals or particular medications. During medication, especially when taking antibiotics, it is advisable to avoid consuming large amounts of alcohol or highly acidic foods to reduce irritation to the gastric mucosa and ensure the effectiveness of the drug. To allow the medication to work more effectively, it is recommended to wait at least half an hour between taking the medication and consuming vinegar. While on medication, patients should avoid drinking alcoholic beverages to prevent potential adverse reactions with cephalosporins.

Vinegar and cephalosporins can be consumed together, but attention should be paid to the timing of medication and alcohol-containing beverages should be avoided. If you have any concerns or experience discomfort, consult your doctor promptly.