Routes of Hepatitis C Virus Transmission
Hepatitis C virus (HCV) is transmitted via three primary routes: (1) bloodborne transmission; (2) mother-to-child (vertical) transmission; and (3) sexual transmission.
Bloodborne transmission includes not only transfusion of HCV-contaminated blood or blood products, but also other forms of blood exposure—for example, accidental skin injury sustained by healthcare workers while treating HCV-infected patients; sharing of needles or syringes among intravenous drug users; and invasive procedures—including tattooing, eyebrow embroidery, or tooth extraction—performed in unregulated settings using inadequately sterilized instruments that puncture the skin. The vast majority of HCV infections (over 90%) occur via bloodborne transmission.
Mother-to-child (vertical) transmission occurs when an HCV-infected pregnant woman transmits the virus to her infant during childbirth. Sexual transmission can occur through unprotected sexual intercourse. HCV is not transmitted via the gastrointestinal or respiratory tracts; therefore, routine work or daily life contact with individuals infected with HCV generally does not pose a risk of infection.