Routes of Hepatitis C Virus Transmission

Aug 05, 2021 Source: Cainiu Health
Dr. Lv Qijun
Introduction
There are three primary modes of transmission: 1. Bloodborne transmission; 2. Mother-to-child (vertical) transmission; 3. Sexual transmission. Bloodborne transmission includes not only transfusion of blood or blood products contaminated with the hepatitis C virus (HCV), but also other forms of blood exposure—for example, healthcare workers sustaining skin injuries while treating HCV-infected patients, or intravenous drug users sharing needles and syringes.

Hepatitis C virus (HCV) is transmitted via three primary routes: (1) bloodborne transmission; (2) mother-to-child (vertical) transmission; and (3) sexual transmission.

Bloodborne transmission includes not only transfusion of HCV-contaminated blood or blood products, but also other forms of blood exposure—for example, accidental skin injury sustained by healthcare workers while treating HCV-infected patients; sharing of needles or syringes among intravenous drug users; and invasive procedures—including tattooing, eyebrow embroidery, or tooth extraction—performed in unregulated settings using inadequately sterilized instruments that puncture the skin. The vast majority of HCV infections (over 90%) occur via bloodborne transmission.

Mother-to-child (vertical) transmission occurs when an HCV-infected pregnant woman transmits the virus to her infant during childbirth. Sexual transmission can occur through unprotected sexual intercourse. HCV is not transmitted via the gastrointestinal or respiratory tracts; therefore, routine work or daily life contact with individuals infected with HCV generally does not pose a risk of infection.

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