Is being positive for HBsAg, HBeAg, and anti-HBc (patterns 1, 3, and 5) considered "major triple positive" (Big Three Positives)?
Apr 10, 2023
Source: Cainiu Health
Dr. Jiang Weimin
Introduction
A positive result for items 1, 3, and 5 in the hepatitis B panel usually indicates "big three positive" (major positivity). The hepatitis B serological panel consists of five components: hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (HBsAb), hepatitis B e-antigen (HBeAg), hepatitis B e-antibody (HBeAb), and hepatitis B core antibody (HBcAb). If test results show positivity for item 1 (HBsAg), item 3 (HBeAg), and item 5 (HBcAb), it indicates infection with the hepatitis B virus and is diagnosed as "big three positive."
HBV 135 positive usually indicates "big three positive." It is recommended to seek medical attention promptly for further evaluation. Once the condition is confirmed, appropriate treatment should be initiated immediately to control the disease progression. The detailed analysis is as follows:
The hepatitis B serological panel consists of five markers: hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (HBsAb), hepatitis B e-antigen (HBeAg), hepatitis B e-antibody (HBeAb), and hepatitis B core antibody (HBcAb). If test results show positivity for HBsAg (item 1), HBeAg (item 3), and HBcAb (item 5), it indicates infection with the hepatitis B virus and confirms the "big three positive" status. During this stage, the hepatitis B viral load is typically high, and patients may experience significant liver-related symptoms such as nausea, vomiting, and aversion to oily foods.
Treatment generally involves antiviral medications such as adefovir dipivoxil capsules, entecavir tablets, or lamivudine capsules, used under the guidance of a physician.
