What disease does "big three positive" indicate in its progression?

Jun 05, 2023 Source: Cainiu Health

Dr. Jiang Weimin

Introduction

The progression of "three positives" (large three Yang) typically leads to chronic hepatitis B, cirrhosis, and liver cancer. If not promptly controlled, it can result in active viral replication, destruction of liver cells, severe impairment of liver function, and development of liver fibrosis, which may progress to cirrhosis. Due to severe liver damage, malignant diseases may arise, leading to the development of liver cancer. Patients are advised to seek timely medical treatment when experiencing physical discomfort.

　　The progression of "Big Three Positive" (HBeAg-positive chronic hepatitis B) usually leads to chronic hepatitis B, liver cirrhosis, and liver cancer. The specific analysis is as follows:

　　1. Chronic Hepatitis B

　　"Big Three Positive" typically indicates active hepatitis B virus infection, suggesting that the patient may have developed hepatitis B. If not promptly controlled, this can lead to active viral replication and destruction of liver cells, resulting in chronic hepatitis B.

　　2. Liver Cirrhosis

　　If patients with "Big Three Positive" do not receive timely antiviral treatment, severe liver damage may occur, leading to liver fibrosis and eventually liver cirrhosis. Patients at this stage commonly experience fatigue, decreased appetite, indigestion, and other discomforts.

　　3. Liver Cancer

　　Liver cancer is a malignant tumor occurring in the liver. When "Big Three Positive" patients do not receive timely treatment, severe liver damage can trigger malignant changes, leading to the development of liver cancer. At this stage, patients may present with progressive weight loss, fever, vomiting, and diarrhea.

　　It is recommended that patients seek medical attention promptly upon experiencing any physical discomfort to avoid delays in treatment. During treatment, adequate rest, healthy lifestyle habits, regular作息 (daily routines), and avoiding late nights and excessive fatigue are essential to support recovery.

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"Big three positives" refers to hepatitis B virus infection. Under normal circumstances, hepatitis B is generally not hereditary. Specifically: In summary, if a patient is diagnosed with hepatitis B, they should seek treatment at a professional infectious diseases department, receive standardized treatment under the guidance of a physician, have regular follow-up visits, and control disease progression.

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Does changing from "big three positive" to "small two positive" indicate improvement or worsening?

"Big three positives" usually refers to the "big three positives" of hepatitis B, while "small two positives" usually refers to the "small two positives" of hepatitis B. Whether the transition from hepatitis B big three positives to small two positives indicates improvement or worsening of the condition needs to be comprehensively evaluated based on specific medical test results. If the quantitative level of hepatitis B virus DNA is low and liver function is normal, it typically indicates an improvement in the condition.

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What causes flank pain and back pain in hepatitis B "big three positives"? What should be done?

Pain and distension in both sides of the rib cage, along with back pain, in individuals with hepatitis B "big three positive" may be caused by physiological factors or pathological factors such as thoracic spine trauma or liver damage, requiring targeted treatment. If adequate rest is not observed during illness and excessive physical labor is performed, the condition may worsen, leading to such symptoms.

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Can Hepatitis B "Big Three Positive" Turn Negative?

In general, "big three positives" of hepatitis B refers to a type of viral hepatitis B infection, which is currently difficult to turn negative. However, for patients who are asymptomatic and have normal liver function, observation without specific treatment may be appropriate. For those patients with symptoms and abnormal liver function, timely treatment and regular follow-up are necessary in order to monitor disease progression and treatment response promptly.

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Is it contagious if my partner has the "big three positives"?

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Can patients with "big three positive" hepatitis B eat chives?

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What is the difference between "big three positive" and "small three positive" in hepatitis B?

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