What drugs are contraindicated in patients with severe hepatic impairment?
Feb 25, 2023
Source: Cainiu Health
Dr. Yang Ziqi
Introduction
Drugs contraindicated in patients with severe hepatic impairment include cefoperazone sodium and sulbactam sodium for injection, diethylstilbestrol tablets, cytarabine for injection, oxytetracycline tablets, and tetracycline hydrochloride tablets. In summary, all medications for patients with severe hepatic impairment must be taken under the guidance of a physician to avoid adverse outcomes.
Generally, drugs contraindicated in patients with severe hepatic insufficiency include cefoperazone sodium and sulbactam sodium for injection, diethylstilbestrol tablets, cytarabine for injection, oxytetracycline tablets, and tetracycline hydrochloride tablets. The specific analysis is as follows:
1. Cefoperazone Sodium and Sulbactam Sodium for Injection
Cefoperazone sodium and sulbactam sodium for injection belong to the class of antibiotic medications and generally exert effective antibacterial and bactericidal effects. In patients with severe liver dysfunction, use of this drug may lead to elevated transaminase levels and cause coagulation disorders.
2. Diethylstilbestrol Tablets
Diethylstilbestrol tablets are hormonal agents primarily used clinically to supplement insufficient estrogen levels in the body. Administration of hormonal drugs in patients with severe hepatic insufficiency increases the burden on the liver, potentially worsening the underlying condition.
3. Cytarabine for Injection
Cytarabine for injection is a commonly used chemotherapeutic agent in clinical practice, primarily indicated for the treatment of acute leukemia, particularly during the induction remission and maintenance consolidation phases. In patients with severe liver dysfunction, administration of toxic drugs like cytarabine may impair detoxification processes, leading to secondary toxic liver disease or exacerbation of hepatic cirrhosis.
4. Oxytetracycline Tablets
Oxytetracycline tablets are primarily used to treat rickettsial diseases, mycoplasma infections, chlamydial infections, brucellosis, cholera, plague, and granuloma inguinale. As a tetracycline-class antibiotic, oxytetracycline is a broad-spectrum bacteriostatic agent. However, this class of drugs is unsuitable for patients with severe hepatic insufficiency, as their use may result in hepatocellular necrosis and fatal fatty liver disease.
5. Tetracycline Hydrochloride Tablets
Tetracycline hydrochloride tablets belong to the tetracycline class of antimicrobial agents, with tetracycline as the main active ingredient. It is a broad-spectrum antibiotic exhibiting potent bactericidal activity at high concentrations. However, these drugs can cause certain liver damage; therefore, they are contraindicated in patients with severe hepatic dysfunction.
In summary, all medications for patients with severe hepatic insufficiency must be taken strictly under the guidance of a physician to avoid adverse outcomes.
