Can tretinoin cream be used long-term?
Generally, if the skin is sensitive, tretinoin cream should not be used for prolonged periods. However, in cases of severe facial acne, long-term use of this medication may be necessary under medical supervision. It is recommended to use tretinoin cream under the guidance of a healthcare professional and adjust the treatment regimen according to medical advice. The details are as follows:

Tretinoin cream is a derivative of vitamin A and has anti-proliferative and anti-keratinization effects. For individuals with sensitive skin, long-term use is generally not recommended. Prolonged use may interfere with keratinocyte differentiation and proliferation, potentially increasing skin sensitivity and susceptibility to external irritants, leading to allergic skin conditions.
For patients with mild to moderate acne or those requiring maintenance therapy, tretinoin cream may be used long-term under a doctor's supervision. Long-term application can help control acne outbreaks, improve skin texture, and reduce the formation of acne scars. However, during extended use, it is essential to follow medical instructions, monitor skin reactions closely, and adjust the frequency and dosage accordingly.
During treatment, proper skin moisturization and sun protection are important. Additionally, avoid using other irritating products simultaneously, such as skincare items containing alpha-hydroxy acids (AHA) or salicylic acid, to prevent excessive skin irritation.