The Efficacy and Side Effects of Celecoxib Capsules

Generally, Celecoxib capsules have the following therapeutic effects: relieving osteoarthritis pain, treating rheumatoid arthritis, alleviating acute pain, improving symptoms of ankylosing spondylitis, and reducing postoperative inflammatory responses. Possible adverse effects include gastrointestinal reactions, allergic reactions, cardiovascular system reactions, nervous system reactions, and systemic reactions. Details are as follows:

I. Therapeutic Effects

1. Relief of Osteoarthritis Pain: Celecoxib capsules effectively reduce joint pain caused by osteoarthritis and help patients regain their ability to perform daily activities. By inhibiting the activity of cyclooxygenase-2 (COX-2), they decrease the synthesis of inflammatory mediators called prostaglandins, thereby exerting anti-inflammatory and analgesic effects.

2. Treatment of Rheumatoid Arthritis: For patients with rheumatoid arthritis, Celecoxib capsules can reduce joint swelling, pain, and stiffness, improving their quality of life. Its selective inhibition of COX-2 helps reduce adverse reactions in the gastrointestinal tract and other systems.

3. Relief of Acute Pain: Celecoxib capsules can be used to treat pain caused by acute injuries or after surgery. By inhibiting the transmission of pain signals, it alleviates pain sensation and promotes recovery.

4. Improvement of Symptoms of Ankylosing Spondylitis: Celecoxib capsules also demonstrate efficacy in patients with ankylosing spondylitis. They can reduce inflammation and pain in the spine and joints, helping patients maintain spinal flexibility and normal posture.

5. Reduction of Postoperative Inflammatory Response: After certain surgical procedures, Celecoxib capsules can be used to reduce inflammation and pain at the surgical site, promoting wound healing. Their anti-inflammatory effects help reduce postoperative complications and accelerate the patient's recovery process.

II. Side Effects

1. Gastrointestinal Reactions: Some patients may experience gastrointestinal discomfort after taking Celecoxib capsules, such as nausea, vomiting, abdominal pain, diarrhea, and indigestion. These symptoms are usually mild but, in severe cases, may lead to serious consequences such as gastrointestinal bleeding and peptic ulcers.

2. Allergic Reactions: A small number of patients may have allergic reactions to certain components of Celecoxib capsules, presenting as skin itching, rash, urticaria, and other symptoms. In rare cases, allergic reactions may trigger severe systemic reactions such as dyspnea and laryngeal edema, which require immediate medical attention.

3. Cardiovascular System Reactions: Celecoxib capsules may affect the cardiovascular system, causing symptoms such as palpitations and tachycardia. In extreme cases, they may induce heart failure, thrombophlebitis, and further increase the burden on the cardiovascular system.

4. Nervous System Reactions: Nervous system reactions are among the common side effects of Celecoxib capsules, including dizziness, headache, neuralgia, vertigo, and other symptoms. Additionally, the drug may affect the optic and auditory nerves, leading to blurred vision, eye pain, ear pain, tinnitus, and hearing abnormalities.

5. Systemic Reactions: Celecoxib capsules may also cause systemic reactions such as fever, fatigue, weakness, dyspnea, bleeding, and joint pain. These symptoms may be related to the drug's effects on multiple body systems or may be associated with individual patient differences.

When using this medication, patients should strictly follow the doctor's instructions, paying attention to dosage and duration of treatment to minimize the occurrence of side effects. Meanwhile, during the course of treatment, patients should closely monitor their physical condition, and if any discomfort occurs, they should stop taking the medication immediately and seek medical attention.