Can hemophilia be detected through blood tests?

Sep 18, 2025 Source: Cainiu Health

Dr. Liu Feng

Introduction

In general, hemophilia can be diagnosed through blood tests. Targeted blood examinations can clarify abnormalities in coagulation function and help determine whether a person has hemophilia and the specific type. In addition, although genetic testing is not part of traditional routine blood tests, it is often performed alongside blood tests. By detecting mutations in relevant genes, genetic testing can identify the underlying genetic background.

Hemophilia is a bleeding disorder caused by deficiency of clotting factors, and blood testing is key to diagnosis. Commonly used tests include the coagulation panel (four parameters), which typically shows normal prothrombin time (PT) but prolonged activated partial thromboplastin time (APTT), indicating an abnormality in the intrinsic coagulation pathway and guiding further diagnostic evaluation. Based on these findings, clotting factor activity assays can accurately identify the type and level of deficient clotting factor—for example, factor VIII deficiency in hemophilia A and factor IX deficiency in hemophilia B—allowing definitive diagnosis and differentiation between types.

Additionally, although genetic testing is not part of traditional routine blood tests, it is often performed alongside blood tests. By detecting mutations in relevant genes, it can clarify the genetic background and help assess the risk of hereditary transmission.

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What diseases can be detected by the five-item coagulation test?

Under normal circumstances, the five routine coagulation tests refer to indicators including prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, thrombin time (TT), and D-dimer. The coagulation panel may help detect conditions such as thrombocytopenic purpura, pulmonary embolism, hemophilia, acute myocardial infarction, and disseminated intravascular coagulation (DIC). If any symptoms of discomfort occur, it is recommended to seek medical attention promptly.

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What diseases can be detected by the four coagulation tests?

The four coagulation tests, including PT, APTT, Fib, and TT, are primarily used to assess whether coagulation function is normal. They are commonly employed as auxiliary diagnostic tools for conditions such as vitamin K deficiency, viral hepatitis, hemophilia, disseminated intravascular coagulation, and thromboembolic diseases. However, these tests can only serve as辅助诊断 methods, and further examinations are necessary if abnormal results are obtained.

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What causes frequent nosebleeds?

Frequent nosebleeds may be caused by dry nasal passages, bad habits, trauma, acute rhinitis, hemophilia, or other reasons. In daily life, to prevent frequent nosebleeds, it is important to keep the nasal cavity moist, avoid excessive nasal irritation, maintain healthy lifestyle habits, and prevent injuries and infections in order to preserve nasal health.