Why stop taking letrozole tablets after 10 years?

Letrozole tablets are primarily used to treat breast cancer. After taking letrozole for 10 years, discontinuation may be considered due to reasons such as achieving the expected therapeutic effect, increased risk of cumulative side effects, changes in disease status, development of drug resistance from long-term use, or decreased individual tolerance. The decision should be made based on a comprehensive assessment of the patient's specific condition. If discomfort or disease fluctuations occur after stopping the medication, prompt medical consultation and follow-up are recommended.

1. Therapeutic goals achieved: Letrozole is commonly used in adjuvant therapy for breast cancer. After completing a standard 10-year course, the risk of tumor recurrence is significantly reduced and clinical treatment goals are met. Continued use offers limited additional benefit, so doctors may recommend discontinuation following evaluation.

2. Increased risk of cumulative side effects: Long-term use may lead to osteoporosis, joint pain, and increased risk of cardiovascular diseases. After 10 years of treatment, the cumulative effects of these side effects become more apparent, and continuing the medication may harm health. Therefore, timely discontinuation is necessary to avoid further risks.

3. Changes in disease status: If the disease progresses during treatment—such as tumor metastasis or new lesions developing—letrozole may no longer effectively control the condition. In such cases, doctors will adjust the treatment plan, discontinue the drug, and switch to other effective therapies.

4. Development of drug resistance with long-term use: In some patients, prolonged use may lead to tumor cells becoming resistant to letrozole, reducing its effectiveness in suppressing cancer growth. Continuing the medication would offer little benefit, necessitating discontinuation and a change in treatment approach.

5. Decreased individual tolerance: With aging or changes in underlying health conditions, patients may experience reduced tolerance to the drug, manifesting as severe adverse reactions such as significant gastrointestinal distress or abnormal liver and kidney function. To ensure patient safety, discontinuation is required.

After stopping the medication, patients should follow their doctor’s instructions for regular follow-up visits to monitor disease status and physiological indicators. Maintaining a regular lifestyle, balanced diet, and engaging in moderate, gentle exercise is recommended. Avoiding fatigue and emotional fluctuations, along with proper self-care, can help sustain treatment outcomes.