What medications are used to treat indurative acne?

In daily life, acne often develops on the face due to work-related stress and irregular sleep patterns. Sometimes, these acne lesions develop firm, painful nodules—significantly affecting facial appearance and causing considerable distress. Many individuals thus wonder: What medications are effective for nodular acne?

Medications for Nodular Acne

For localized nodular acne, topical anti-inflammatory agents—such as fusidic acid cream or mupirocin cream—may be applied appropriately. Oral administration of Longdan Xiegan Wan (Gentiana Decoction for Draining Liver Fire) may also be considered to clear heat and detoxify. While using these medications, patients should strictly avoid squeezing or picking at lesions, as this can exacerbate inflammation and worsen nodule formation.

Nodular acne is a severe form of acne characterized by deep-seated inflammatory lesions. It arises when intense inflammation causes follicular wall rupture, allowing follicular contents to spill into the dermis. This process is further driven by various pro-inflammatory cytokines and chemokines. Although the pathogenesis of nodular acne is multifactorial, its underlying causes largely overlap with those of common acne—except that the inflammatory response penetrates deeper into the skin. Primary contributing factors include relative excess of androgens or an imbalance in the estrogen-to-androgen ratio; abnormal hyperkeratinization of the pilosebaceous duct; excessive sebum production; infection with Propionibacterium acnes; and subsequent immune-mediated inflammatory responses. These interrelated factors collectively influence all stages of acne development—including the formation of nodules.

Dietary recommendations emphasize light, easily digestible foods. Patients should minimize intake of greasy or spicy, irritating foods, and instead consume more vitamin-rich vegetables and fruits. We hope this information proves helpful!