Is a high lupus anticoagulant level indicative of lupus erythematosus?

A high level of lupus anticoagulant is not necessarily indicative of systemic lupus erythematosus (SLE), but it may serve as one of its markers. Lupus anticoagulant is an antibody acting on phospholipids. Its elevation can be caused by various factors, including but not limited to SLE, long-term use of psychiatric medications, HIV-related infections, multiple thrombotic events, spontaneous abortion, and malignancies. Systemic lupus erythematosus is a chronic, relapsing autoimmune disease. Lupus anticoagulant is one of the laboratory criteria used in diagnosing SLE. Elevated lupus anticoagulant levels may also be associated with other autoimmune diseases. When a high level of lupus anticoagulant is detected, timely medical evaluation is necessary. A comprehensive analysis incorporating clinical symptoms and other laboratory findings should be conducted to determine the specific underlying cause.