What are the consequences of a rapid decrease in uric acid?

The consequences of uric acid levels dropping too quickly mainly include: 1. Worsening gout attacks: When uric acid levels drop rapidly, urate crystals deposited in the joints dissolve quickly, forming microcrystals. These microcrystals can irritate the joints, triggering acute gout attacks and worsening joint redness, swelling, pain, and even affecting mobility. 2. Gastrointestinal discomfort: Rapid decreases in uric acid levels may irritate the gastrointestinal tract, causing symptoms such as nausea, vomiting, and diarrhea. 3. Allergic reactions: In patients with a history of allergies and hypersensitivity to uric acid, a rapid decline in uric acid levels may induce allergic reactions such as skin itching, swelling, and pain. 4. Kidney damage: Long-term hyperuricemia may lead to uric acid crystal deposition in the kidneys. Rapid uric acid reduction may increase the burden on the kidneys, causing kidney dysfunction, manifested as edema, hypertension, and in severe cases, potentially leading to renal failure.