How to taper corticosteroids in children with nephrotic syndrome
Disease description:
My child has nephrotic syndrome and has been undergoing hormone therapy. I would like to ask how the dosage should be gradually reduced in the later stages of treatment?
Doctor's answer (1)
Dr. Yang Guang
Pediatric nephrotic syndrome is a common kidney disease in children, and its treatment usually involves the use of glucocorticoids. Although hormone therapy is effective, long-term use may cause a series of side effects; therefore, it is important to safely and effectively reduce the dosage of hormones.
The child's condition will be evaluated, including improvements in indicators such as proteinuria, edema, and blood pressure, to determine whether conditions are suitable for reducing the hormone dosage. When the medical condition permits, the glucocorticoid dosage will be gradually reduced—for example, medications such as prednisone and methylprednisolone. The initial dose is determined based on the patient's age and weight, and then gradually tapered down to a maintenance dose. In addition to reducing the hormone dosage, treatment plans may also be adjusted according to the child's specific condition, such as considering the addition of other medications like immunosuppressants or diuretics.
During the tapering process, in addition to pharmacological treatment, attention should also be given to comprehensive management including dietary control and lifestyle modifications. Even after the hormone dosage has been reduced or discontinued, the child still requires regular follow-up tests, such as urinalysis and renal function assessments, to monitor any changes in the disease status.
