Is a D-dimer level of 2.49 mg/L serious?

Mar 28, 2025 Source: Cainiu Health
Disease description:

Recently, I've been feeling chest tightness and shortness of breath. After visiting the hospital for tests, my D-dimer level was found to be 2.49 mg/L. Is this value serious? Does it mean there is a major health issue?

Doctor's answer (1)
Dr. Tian Hongbo

Under normal circumstances, whether a D-dimer level of 2.49 mg/L is serious needs to be comprehensively evaluated based on the patient's specific condition. If it is due to the body's normal stress response, it generally is not serious. However, if it is caused by thrombotic diseases, it may indicate a serious condition.

Normally, the reference range for D-dimer is generally below 0.5 mg/L, although this may vary slightly depending on the testing method used. When D-dimer levels rise to 2.49 mg/L, it indeed exceeds the normal range. If this increase occurs after surgery, trauma, childbirth, or similar situations, it is usually a normal stress response of the body and typically decreases gradually as the body recovers, indicating a generally non-serious situation.

However, if the elevated D-dimer level is caused by thrombus formation and the patient experiences symptoms such as difficulty breathing, chest pain, or limb swelling, the situation is relatively serious and timely anticoagulant therapy should be initiated to prevent thrombotic events. Additionally, if the elevation is caused by other factors such as inflammatory reactions or tumors, appropriate treatment measures should be taken based on the specific situation.

In daily life, it is recommended that patients maintain a healthy lifestyle, such as balanced nutrition, moderate exercise, smoking cessation, and limiting alcohol consumption, to reduce the risk of thrombus formation.