What causes angular cheilitis?

Apr 16, 2025 Source: Cainiu Health
Disease description:

I've had recurring sores at the corners of my mouth, which are both painful and itchy. Applying lip balm hasn't helped. What exactly is causing these mouth corner sores?

Doctor's answer (1)
Dr. Liu Chao

Angular cheilitis, known in medical terms as perleche, is a common oral condition that may be caused by vitamin deficiencies, environmental factors, poor hygiene, allergies, or infections.

Vitamin deficiencies, especially of B-complex vitamins such as B2 and B6, as well as trace elements like iron and zinc, may lead to angular cheilitis. Harsh environmental conditions, such as cold dry weather and exposure to wind and sun, can cause dryness of the lips and subsequently trigger angular cheilitis. Long-term poor oral hygiene, bacterial infection, or fungal infection (such as Candida) can also cause this condition.

Frequently licking dry lips may result in bacterial growth after saliva evaporation, which can lead to angular cheilitis. Allergies to certain foods, medications, or cosmetic ingredients may also contribute to its development. Bacterial, fungal, or herpes viral infections are other common causes. Improper oral hygiene or a weakened immune system increases susceptibility to these pathogens.

Treatment for angular cheilitis typically involves addressing the underlying cause, such as supplementing with appropriate vitamins and minerals, improving oral hygiene, and avoiding contact with irritants. In severe cases, doctors may prescribe antifungal or antibiotic ointments for topical application.

Symptoms of angular cheilitis include erosion at the corners of the mouth, dryness and peeling of the lips, pain, and difficulty opening the mouth. To prevent and treat angular cheilitis, it is recommended to maintain good dietary habits, ensure balanced nutrition, practice proper oral hygiene, and avoid bad habits.