The most important difference between serum and plasma
Apr 07, 2023
Source: Cainiu Health
Dr. Zhang Heyang
Introduction
The differences between serum and plasma are usually categorized into composition, appearance, source, etc., with the main difference being their composition. In addition, the distinction between serum and plasma also includes their different functions. Plasma primarily contains proteins and clotting factors needed by the body and is typically used when there is an abnormality in blood coagulation function, whereas serum contains immunoglobulins and is generally used during extraction processes.
The differences between serum and plasma are usually categorized into composition, appearance, source, etc., with the main difference being their composition.
1. Composition
Serum does not contain fibrinogen or calcium ions, whereas plasma contains a variety of components, including various proteins. Plasma also contains white blood cells and platelets, and has strong coagulation factors.
2. Appearance
Serum is separated from blood after it has clotted and appears as a colorless, transparent liquid. In contrast, plasma is typically light yellow, making the two clearly distinguishable in color.
3. Source
Blood consists of blood cells and plasma. Plasma is obtained by adding an anticoagulant to blood and then removing the blood cells; thus, plasma retains anticoagulant properties. Serum, on the other hand, is the fluid separated from blood after natural clotting has occurred. Serum lacks anticoagulant ability and will form a clot.
In addition, the differences between serum and plasma also include their distinct functions. Plasma is ideal for supplementing proteins and coagulation factors required by the body and is commonly used when coagulation function is impaired. Serum contains immunoglobulins and is generally used during extraction processes.
