What are the symptoms of syphilis on the glans penis?
Syphilis is a chronic, systemic sexually transmitted disease caused by the bacterium *Treponema pallidum*. When syphilis infection affects the genital area, symptoms on the glans penis in males may include hard chancre, erythema, moist warts, lymphadenopathy, and systemic symptoms. It is recommended to seek medical attention promptly and receive treatment under the guidance of a healthcare provider. The specific manifestations are as follows:
1. Hard chancre: This is the main feature of primary syphilis, presenting as a painless ulcer on the glans penis with well-defined margins, a flat base, and firm consistency. Chancres are usually solitary but may occasionally be multiple. They form when *Treponema pallidum* invades the skin or mucous membranes, triggering a localized inflammatory response that ultimately leads to ulceration.
2. Erythema: In secondary syphilis, patients may develop red macules or papules on the glans penis or surrounding genital areas. These skin lesions can appear isolated or coalesce into larger patches. Typically non-itchy and painless, they are highly contagious and result from widespread dissemination of *Treponema pallidum* throughout the body.
3. Moist warts: Syphilis may cause wart-like growths in the genital region characterized by a moist surface and irregular borders. These lesions resemble condylomata acuminata (genital warts), but differ in that they are caused by *Treponema pallidum* rather than viral infection.
4. Lymphadenopathy: During the early stage of syphilis, painless swelling of regional lymph nodes—particularly the inguinal lymph nodes—may occur. This results from *Treponema pallidum* entering the bloodstream and stimulating an immune response that leads to lymph node enlargement.
5. Systemic symptoms: In addition to local manifestations, patients with secondary syphilis may experience systemic symptoms such as fever, fatigue, and muscle aches. These arise when *Treponema pallidum* spreads via the bloodstream, causing a systemic inflammatory response.
For individuals diagnosed with syphilis, treatment should follow medical advice and typically includes antibiotics such as procaine penicillin for injection, benzathine penicillin for injection, or potassium furoate benzylpenicillin for injection. Additionally, practicing safe sex, including consistent condom use, can effectively reduce the risk of syphilis transmission.