How to Get Rid of Cold Sores at the Corners of the Mouth in One Day
Blisters at the corners of the mouth are not solely caused by “excess internal heat” (a traditional Chinese medicine concept), but may also result from infection with the herpes simplex virus. Therefore, if blisters appear at the mouth corners, appropriate treatment targeting the underlying cause is essential. Below, we outline effective methods for rapidly resolving such blisters:

How to Eliminate Mouth-Corner Blisters Within One Day
If mouth-corner blisters are severe due to “excess internal heat,” applying natural aloe vera gel may be highly effective, as it possesses strong antibacterial properties. For patients experiencing itching or pain at the blister site, aloe vera gel provides a cooling sensation and effectively alleviates these discomforts. Typically, pain subsides significantly after application, and repeated applications can resolve symptoms entirely.
Alternatively, cod liver oil capsules may be punctured and the oil applied directly to the affected area. Additionally, vitamin B2 tablets can be crushed into a fine powder and sprinkled onto the lesion. If cod liver oil or vitamin B2 supplements are unavailable, boiled rice water (the starchy water remaining after cooking rice) or persimmon frost (a traditional remedy derived from dried persimmons) may serve as alternative treatments.
Blisters at the mouth corners may also indicate oral herpes (herpes labialis). Initial symptoms include a burning sensation, followed by clusters of small vesicles, erosion, and crusting. The condition typically lasts about one week and may recur. Small, pinhead-sized vesicles commonly appear on the lip mucosa—often in clusters, sometimes involving two or three clusters—and are accompanied by mild burning sensations. While the condition may resolve spontaneously within approximately one week, recurrences are common. If blisters are caused by oral herpes, pharmacological treatment is recommended.
Standard antiviral agents—including ribavirin and moroxydine—can be used to treat herpes simplex infections; however, acyclovir demonstrates superior efficacy. Acyclovir exhibits high specificity and affinity for herpes viruses, enabling efficient uptake by infected cells, where it triggers intracellular chemical reactions that inhibit viral replication. During the early stage of blister formation, topical application of acyclovir ophthalmic ointment twice daily provides effective adjunctive therapy.
We hope the above information proves helpful. Wishing you good health and happiness!