What liver function tests are included in a follow-up examination?
Jun 05, 2023
Source: Cainiu Health
Dr. Jiang Weimin
Introduction
Liver function is typically reevaluated by testing alanine aminotransferase (ALT) and aspartate aminotransferase (AST), direct and indirect bilirubin, coagulation factors, etc. ALT and AST are primarily present in the liver and are important indicators in liver function assessment. They reflect the condition of hepatocytes, such as whether there is hepatocellular damage or necrosis. Elevated transaminase levels may be observed in diseases such as hepatitis, cirrhosis, and cancer.
Liver function is typically reevaluated by testing alanine aminotransferase (ALT) and aspartate aminotransferase (AST), direct and indirect bilirubin, coagulation factors, among others. Specific details are as follows:
1. Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST)
ALT and AST are primarily found in the liver and are important indicators in liver function tests. They reflect the condition of hepatocytes, such as whether liver cells are damaged or necrotic. Elevated transaminase levels may be seen in diseases such as hepatitis, cirrhosis, and cancer.
2. Direct Bilirubin and Indirect Bilirubin
Bilirubin levels mainly reflect bilirubin metabolism and bile stasis. An increase in direct bilirubin indicates hepatocyte degeneration or necrosis, leading to disrupted bilirubin metabolism or intrahepatic cholestasis. Elevated indirect bilirubin suggests the occurrence of hemolytic jaundice.
3. Coagulation Factors
The liver is the primary organ responsible for synthesizing coagulation factors. A reduction in coagulation factors indirectly indicates liver damage, thereby impairing the liver cells' ability to produce these factors.
In addition to the above tests, evaluations may also include serum protein levels, assessments of liver cell injury, and tests of metabolic and detoxification functions. If test results are abnormal, it is essential to promptly seek diagnosis and treatment at a正规 medical institution.
