Can I still receive the 9-valent HPV vaccine if I am sexually active?

Mar 14, 2025 Source: Cainiu Health
Dr. Yang Ziqi
Introduction
The 9-valent vaccine refers to the 9-valent recombinant human papillomavirus (HPV) vaccine. Under normal circumstances, individuals who are sexually active can receive the 9-valent recombinant HPV vaccine, and if needed, should do so under a doctor's guidance. The 9-valent recombinant HPV vaccine provides immune protection against nine high-risk and low-risk types of HPV virus, including HPV 16, HPV 18, and others.

The 9-valent vaccine refers to the 9-valent recombinant human papillomavirus (HPV) vaccine. Generally, individuals who are sexually active can still receive the 9-valent recombinant HPV vaccine. If needed, vaccination should be conducted under a doctor's guidance. Detailed explanation is as follows:

The 9-valent recombinant HPV vaccine provides immune protection against nine high-risk and low-risk HPV types. It covers major high-risk subtypes such as HPV 16 and HPV 18, which are primarily responsible for cervical cancer, as well as some low-risk subtypes that cause benign lesions such as genital warts. Even after becoming sexually active, individuals remain at risk of infection with other HPV subtypes they have not yet encountered. Vaccination can stimulate the immune system to produce specific antibodies, reducing the likelihood of subsequent infection with those high-risk cancer-causing or disease-causing subtypes, thereby providing ongoing protection for women's health.

Although sexual activity increases the possibility of HPV exposure, it does not mean that an individual has been infected with all HPV subtypes covered by the vaccine. For specific HPV subtypes an individual has not previously encountered, the vaccine can still trigger an immune response and provide effective protection. Moreover, the body's immune system has a certain memory function. Immune memory cells formed after vaccination can rapidly initiate an immune response upon encountering the corresponding virus, helping to eliminate the virus. Even in individuals with prior sexual experience, vaccination still plays a positive role in preventing disease progression and reducing the risk of infection.

After vaccination, it is important to maintain a light diet, avoid spicy or greasy foods, ensure adequate rest and sleep, and avoid excessive fatigue.

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